Supplement Protocol - Hormora

Supplement Protocol

Food-first targeted support for specific hormonal imbalances

Supplements should complement, never replace, a nutrient-dense diet. Always prioritize food sources first.

πŸ“‹
This is a reference database, not your personal protocol.
Your personalized supplement plan is in your 60-Day Protocol. Start there. Use this page to learn more about individual supplements or explore options beyond your protocol.
✨ Build My Stack 0 selected

Click the checkbox on any supplement below to add it to your stack and generate a daily timing schedule.

πŸ“‹ How to Use This Page

1Start with your scores β€” Filter by the hormone systems flagged in your Hormora analysis
2Or choose a condition β€” Have PCOS, perimenopause, or gut issues? Use condition filters for curated stacks
3Build your stack β€” Check supplements to add them, then view your personalized daily schedule
4Shop directly β€” Click any supplement name to purchase from our recommended sources
🧬 Filter by Hormone System
Your Hormora Scores
Not Scored (but often relevant)
Foundational
🎯 Filter by Condition

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⚑ Quick-Start Stacks
Curated supplement combinations for specific goals β€” click to filter
🎯
PCOS Support Stack
Insulin sensitizers + androgen balance + ovulation support for polycystic ovarian syndrome.
View stack details β†’
🌿
Gut Repair Stack
Heal gut lining, support microbiome, optimize bile flow for hormone metabolism.
View stack details β†’
😌
Stress Recovery Stack
Calm the HPA axis, support adrenal function, improve sleep quality.
View stack details β†’
πŸ¦‹
Thyroid Support Stack
Support T4β†’T3 conversion, provide building blocks, address common deficiencies.
View stack details β†’
🌸
Fertility Support Stack
Egg quality, ovulation support, hormone balance for conception.
View stack details β†’
πŸ”„
Perimenopause Stack
Support declining progesterone, manage estrogen fluctuations, ease the transition.
View stack details β†’
🎯
PCOS Protocol Guide
Multi-system approach targeting insulin resistance, androgen excess, and ovulation
πŸ’Š Core Stack
  • Inositol β€” 4g daily (40:1 Myo:D-Chiro ratio), split AM/PM
  • Berberine β€” 500mg 2-3x daily with meals
  • Magnesium β€” 400-600mg before bed
  • D3+K2 β€” 2000-4000 IU + 100mcg daily
⏰ Timing Notes
Inositol: Split dose β€” 2g morning, 2g evening for steady levels.
Berberine: Cycle 8 weeks on, 2 weeks off. Take with meals to reduce GI upset.
NAC: Empty stomach AM for best absorption.
πŸ”„ Why This Works
PCOS is fundamentally an insulin problem driving androgen excess. Inositol restores insulin signaling at the cellular level. Berberine activates AMPK (like metformin). Together they address the root cause, not just symptoms.
⚠️ Cautions
Berberine + Metformin: Don't combine β€” similar mechanisms, risk of hypoglycemia.
Vitex: Avoid if on hormonal birth control.
Timeline: Allow 3-6 months for cycle regulation.
🌿
Gut Repair Protocol Guide
Heal the gut lining, rebalance microbiome, optimize hormone metabolism
πŸ’Š Core Stack
  • L-Glutamine β€” 5g 2x daily on empty stomach
  • Collagen/Gelatin β€” 1-2 tbsp daily with meals
  • Lactoferrin β€” 250mg daily on empty stomach
  • S. boulardii β€” 250-500mg daily
  • Taurine β€” 500-1000mg with dinner
πŸ”— Gut-Hormone Connection
Estrobolome: Gut bacteria metabolize estrogen β€” dysbiosis = estrogen dominance.
Thyroid: 20% of T4β†’T3 conversion happens in the gut.
Cortisol: Gut inflammation drives HPA axis dysfunction.
⏰ Timing Notes
L-Glutamine: Empty stomach is critical β€” AM before food, PM before bed.
Lactoferrin: Away from iron supplements (competes for binding).
S. boulardii: Can take with or without food, survives stomach acid.
⚠️ Cautions
Die-off reactions: Start slow, increase gradually over 2 weeks.
SIBO: If diagnosed, work with practitioner β€” some supplements can worsen overgrowth.
😌
Stress Recovery Protocol Guide
Calm the HPA axis, restore adrenal reserves, improve sleep architecture
πŸ’Š Core Stack
  • Magnesium Glycinate β€” 400-600mg before bed
  • B5 (Pantothenic Acid) β€” 500mg AM with breakfast
  • Glycine β€” 3g before bed
  • NAC β€” 600mg AM empty stomach
  • GABA β€” 250-500mg before bed (start low)
πŸ”„ Why This Works
Chronic stress depletes magnesium, B5, and vitamin C faster than you can replace them. B5 is the "anti-stress vitamin" β€” required for cortisol synthesis. Glycine and GABA calm the nervous system for deeper sleep when cortisol should be lowest.
⏰ Timing Notes
AM stack: B5, NAC, Vitamin C β€” support daytime cortisol rhythm.
PM stack: Magnesium, Glycine, GABA β€” promote evening cortisol decline and sleep.
⚠️ Cautions
GABA: Start with 250mg β€” can cause drowsiness or vivid dreams.
Timeline: Adrenal recovery takes 3-6 months minimum. Be patient.
πŸ¦‹
Thyroid Support Protocol Guide
Provide building blocks, support conversion, address common deficiencies
πŸ’Š Core Stack
  • Brazil Nuts β€” 1-2 daily (natural selenium source)
  • Iodine (Kelp) β€” 250mcg 2x weekly only
  • Zinc β€” 15-30mg daily with food
  • L-Tyrosine β€” 500-1000mg AM empty stomach
  • B12 β€” 1000mcg sublingual
πŸ”„ Why This Works
Thyroid hormones need tyrosine + iodine as building blocks. Selenium activates the deiodinase enzymes that convert T4β†’T3. Most hypothyroid patients are deficient in one or more of these.
⏰ Timing Notes
L-Tyrosine: Empty stomach AM, 30 min before food.
Iodine: Only 2x weekly β€” excess suppresses thyroid.
Thyroid meds: Take Brazil nuts/zinc 4+ hours away from thyroid medication.
⚠️ Cautions
Hashimoto's: Get TPO antibodies tested first β€” excess iodine can trigger flares.
Already on meds: These supplements support, not replace, thyroid medication.
🌸
Fertility Support Protocol Guide
Optimize egg quality, support ovulation, balance hormones for conception
πŸ’Š Core Stack
  • Inositol β€” 4g daily (improves egg quality)
  • CoQ10 β€” 200-600mg daily (mitochondrial energy for eggs)
  • Methylfolate + B12 β€” 800mcg + 1000mcg (neural tube, MTHFR)
  • Vitamin E β€” 400 IU daily (uterine lining)
  • Vitex β€” 400-1000mg AM (progesterone support)
  • Zinc β€” 15-30mg daily (egg development)
πŸ”„ Cycle Timing
Follicular phase (Days 1-14): Focus on egg quality β€” Inositol, CoQ10, antioxidants.
Luteal phase (Days 15-28): Support implantation β€” Vitex, B6, Vitamin E.
⏰ Timeline
Egg maturation takes ~90 days. Start supplements 3 months before actively trying. CoQ10 is especially important for women 35+ as levels decline with age.
⚠️ Cautions
Vitex: Discontinue once pregnant. Don't use with IVF medications.
Folate: Use methylfolate, NOT synthetic folic acid (important for MTHFR).
πŸ”„
Perimenopause Protocol Guide
Support declining progesterone, manage estrogen fluctuations, ease the transition
πŸ’Š Core Stack
  • Magnesium β€” 400-600mg before bed (sleep, mood)
  • B6 (P5P) β€” 50-100mg daily (progesterone support)
  • Vitex β€” 400-1000mg AM (if still cycling)
  • Calcium D-Glucarate β€” 500mg daily (estrogen clearance)
  • Vitamin E β€” 400 IU daily (hot flash reduction)
πŸ”„ What's Happening
Perimenopause = progesterone drops first, creating relative estrogen dominance even as estrogen eventually declines. This causes the classic symptoms: irregular cycles, heavier periods, mood swings, sleep issues.
⏰ Phase-Specific
Early peri (still cycling): Vitex + B6 to support remaining progesterone.
Late peri (irregular/stopped): Focus on estrogen metabolism + symptom management.
⚠️ Cautions
Vitex: Stop once periods have ceased for 12+ months.
HRT: These supplements can complement HRT β€” discuss with your doctor.

⏰ Daily Timing At-A-Glance

This is not a list of everything you should take. If any of the supplements in your personalized protocol appear below, these are the best times to take them.

πŸŒ…
Morning
With breakfast
B6, B5, B1, Iodine, Nutritional Yeast, D3+K2, Boron, Brazil Nuts, Vitex, L-Tyrosine, Inositol (half), NAC (empty stomach)
β˜€οΈ
Midday
With largest meal
Chromium, Berberine, Vitamin E, Collagen/Gelatin
πŸŒ†
Evening
With dinner
Oyster/Zinc, Vitamin C, Calcium D-Glucarate, Taurine, Inositol (half)
πŸŒ™
Bedtime
30 min before sleep
Magnesium, Glycine, GABA, Arginine+Ornithine

⚑ Important Interactions

πŸ”„
Zinc + Copper: Oyster supplement naturally balances these. If taking zinc alone, add copper (2mg per 15mg zinc).
⏱️
Iron + Thyroid meds: Separate by 4 hours. Iron blocks thyroid hormone absorption.
🍽️
Fat-soluble vitamins (D, E, K): Always take with meals containing fat for absorption.
β˜•
Magnesium + Coffee: Caffeine depletes magnesium. Take mag 2+ hours after coffee.
πŸ’Š
NAC + Medications: NAC can affect how some medications work. Consult your doctor if on prescriptions.
πŸ₯›
Calcium + Magnesium: Don't take together in high dosesβ€”they compete for absorption. Separate by 2+ hours.
🦴
D3 + K2: Always pair together. D3 increases calcium absorption; K2 directs it to bones (not arteries).

πŸ₯— Food-First Philosophy

Before supplementing, ensure adequate intake of: Brazil nuts (1 daily for selenium), oysters/shellfish (1x weekly for zinc), bone broth (daily for glycine), egg yolks (daily for choline), sun exposure (20+ minutes midday for vitamin D), and sardines/salmon (2-3x weekly for omega-3s).

Hormone Color Key

Estrogen
Progesterone
Cortisol
Insulin
Thyroid
Testosterone
Growth Hormone
Gut Health
Prolactin
βš–οΈ
Estrogen
Detoxification & Balance
β–Ό
Calcium D-Glucarate
Shop β†’
500mg daily between meals
πŸŒ† Evening
?
Non-Fortified Nutritional Yeast
Shop β†’
1-2 tablespoons daily with breakfast
πŸŒ… Morning
?
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
Vitamin E (Whole)
Shop β†’
125-250 IU daily with fat
β˜€οΈ With meal
?
Methylfolate + Methyl B12
Shop β†’
400-800mcg folate + 1000mcg B12 daily
⚑ Use methylated forms, not folic acid πŸŒ… Morning
?
⏰ Timing
Nutritional yeast with breakfast, magnesium before bed
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
πŸ“ Note
Focus on supporting natural detox pathways through diet first
⚠️ Cautions
Pregnancy/Nursing: Consult healthcare provider before using Calcium D-Glucarate.
Medications: D-Glucarate may affect how the body processes certain drugs.
🌸
Progesterone
Production Support
β–Ό

Why this matters: Progesterone counterbalances estrogen β€” it's often the estrogen:progesterone ratio that determines symptoms like heavy periods, PMS, anxiety, and sleep issues. Low progesterone often accompanies estrogen dominance, perimenopause, and fertility issues. It's also depleted by chronic stress (pregnenolone steal). While Hormora doesn't score progesterone directly, it's closely tied to your Estrogen and Cortisol scores.

Vitamin B6 (P5P)
Shop β†’
25-50mg daily with breakfast
πŸŒ… Morning
?
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
Vitamin C (Camu Camu/Acerola)
Camu Camu β†’Acerola β†’
500-1000mg daily
πŸŒ† Anytime
?
Oyster Supplement
Shop β†’
1-2 capsules daily with a meal
⚑ Skip if eating oysters weekly πŸŒ† Evening
?
Vitex (Chasteberry)
Shop β†’
400-1000mg daily in AM
⚑ Best for luteal phase (days 15-28) πŸŒ… Morning
?
CoQ10 (Ubiquinol)
Shop β†’
200-600mg daily with fatty meal
⚑ Ubiquinol form for better absorption πŸŒ… Morning with food
?
⏰ Timing
B6 AM, Magnesium before bed, Oyster supplement with dinner
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
B6 Dosing: Very high doses (200mg+/day long-term) may cause nerve issues. Stick to recommended range.
🧘
Cortisol
Stress Regulation
β–Ό
Magnesium Glycinate
Shop β†’
600-800mg divided (200mg AM, 600mg PM)
πŸŒ… 200mg AM πŸŒ™ 600mg PM
?
B5 (Pantothenic Acid)
Shop β†’
250-500mg daily with food
πŸŒ… Morning
?
Glycine Powder
Shop β†’
3g before bed
⚑ Skip if drinking bone broth daily πŸŒ™ Bedtime
?
NAC (N-Acetyl Cysteine)
Shop β†’
600mg daily on empty stomach AM
πŸŒ… AM empty stomach
?
⏰ Timing
Magnesium split AM/PM, NAC on empty stomach AM, Glycine before bed
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
NAC + Medications: NAC can interact with some blood pressure medications. Consult your doctor.
πŸ“Š
Insulin
Sensitivity Support
β–Ό
Non-Fortified Nutritional Yeast
Shop β†’
1-2 tablespoons daily with breakfast
πŸŒ… Morning
?
Chromium Picolinate
Shop β†’
200mcg with largest meal
β˜€οΈ Largest meal
?
Biotin
Shop β†’
2500-5000mcg daily with food
πŸŒ… Morning
?
Vitamin D3
Shop β†’
2000-3000 IU daily (only if limited sun)
⚑ Skip if getting 20+ min midday sun πŸŒ… Morning with fat
?
Vitamin K2 (MK-7)
Shop β†’
100-200mcg daily (take with D3)
⚑ Only if supplementing D3 πŸŒ… Morning with fat
?
Vitamin B1 (Thiamine)
Shop β†’
50-100mg daily with food
πŸŒ… Morning
?
Inositol (Myo + D-Chiro)
Shop β†’
2-4g daily, split AM/PM doses
πŸŒ… AM + PM
?
Berberine
Shop β†’
500mg 2-3x daily with meals
⚠️ Cycle 8 weeks on/2 weeks off β˜€οΈ With meals
?
Taurine
Shop β†’
500-2000mg daily
πŸŒ† Evening
?
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
⏰ Timing
Nutritional yeast with breakfast, Chromium with largest meal, D3 with breakfast
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
Biotin + Lab Tests: High-dose biotin can interfere with thyroid and cardiac lab tests. Stop 3-5 days before bloodwork.
πŸ¦‹
Thyroid
T3/T4 Production
β–Ό
Iodine (Kelp-based)
Shop β†’
250mcg 2x weekly AM with food
πŸŒ… 2x/week only
?
Oyster Supplement
Shop β†’
1-2 capsules daily with a meal
⚑ Skip if eating oysters weekly πŸŒ† Evening
?
Brazil Nuts (Whole Food)
Shop β†’
1-2 nuts daily (preferred over selenium pills)
πŸŒ… Morning
?
Natural Desiccated Thyroid (NDT)
Shop β†’
30mg daily with breakfast
⚠️ Practitioner supervision required πŸŒ… Morning
?
L-Tyrosine
Shop β†’
500-1000mg daily on empty stomach
πŸŒ… Morning empty stomach
?
⏰ Timing
Iodine AM (2x weekly only), Oyster supplement with dinner
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
Hashimoto's: Excess iodine can trigger flares in autoimmune thyroid conditions. Get tested before supplementing.
NDT: Contains active thyroid hormones. Requires prescription and medical monitoring.
πŸ’ͺ
Testosterone
Natural Production
β–Ό
Oyster Supplement
Shop β†’
1-2 capsules daily with meals
⚑ Skip if eating oysters weekly πŸŒ† Evening
?
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
Boron
Shop β†’
3-6mg daily with breakfast
πŸŒ… Morning
?
Vitamin D3
Shop β†’
2000-4000 IU daily (only if limited sun)
⚑ Skip if getting adequate sun πŸŒ… Morning with fat
?
Vitamin K2 (MK-7)
Shop β†’
100-200mcg daily (take with D3)
⚑ Only if supplementing D3 πŸŒ… Morning with fat
?
Zinc (Picolinate/Bisglycinate)
Shop β†’
15-30mg daily with food
⚑ Only if not taking oyster supplement πŸŒ† With dinner
?
⏰ Timing
Oyster supplement with dinner, D3 with breakfast (if needed), Boron with breakfast
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
Prostate conditions: Consult doctor before using testosterone-supporting supplements if you have prostate issues.
🎯
Prolactin
Regulation
β–Ό

Why this matters: Prolactin rises with chronic stress and suppresses both testosterone and ovulation. It's often elevated in PCOS. High prolactin can cause irregular cycles, low libido, and fatigue. While Hormora doesn't score prolactin directly, it's closely tied to your Cortisol and Testosterone scores.

Vitamin B6 (P5P)
Shop β†’
25-50mg daily with breakfast
πŸŒ… Morning
?
Vitamin E (Whole)
Shop β†’
125-250 IU daily with fat
β˜€οΈ With meal
?
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
Vitex (Chasteberry)
Shop β†’
400-1000mg daily in AM
⚑ Takes 3-6 months for full effect πŸŒ… Morning
?
⏰ Timing
B6 AM, Vitamin E with meals containing fat
πŸ”„ Cycle
4-8 weeks on, 2-3 weeks food-only break
⚠️ Cautions
Breastfeeding: Don't try to lower prolactin if breastfeedingβ€”it's needed for milk production.
πŸ“ˆ
Growth Hormone
Natural GH Support
β–Ό
Glycine Powder
Shop β†’
3-5g before bed
⚑ Skip if drinking bone broth daily πŸŒ™ Bedtime
?
GABA
Shop β†’
250-750mg before bed (start low)
πŸŒ™ Bedtime
?
L-Arginine
Shop β†’
3-5g before bed on empty stomach
⚑ Avoid if history of herpes πŸŒ™ Bedtime
?
L-Ornithine
Shop β†’
2-3g before bed (take with arginine)
πŸŒ™ Bedtime
?
Grass-Fed Collagen/Gelatin
Collagen β†’Gelatin β†’
1-2 tablespoons daily
β˜€οΈ With meals
?
⏰ Timing
Most GH supplements work best before bed on empty stomachβ€”GH is primarily released during deep sleep
πŸ”„ Lifestyle
Sleep quality, resistance training, and fasting all naturally boost GH. Supplements enhance these effects.
⚠️ Cautions
Cancer history: GH can accelerate tumor growth. Consult doctor before using GH-supporting supplements.
Diabetes: GH can affect blood sugar. Monitor closely if diabetic.
🌿
Gut Health
Foundation for All Hormones
β–Ό

Why this matters: Your gut is foundational to ALL hormone systems. The estrobolome (gut bacteria) metabolizes estrogen. 20% of T4β†’T3 thyroid conversion happens in the gut. Gut inflammation drives cortisol. While Hormora doesn't score gut health directly, fixing the gut often improves all six of your hormone scores.

L-Glutamine
Shop β†’
5g 2x daily on empty stomach
πŸŒ… AM + PM empty stomach
?
Lactoferrin
Shop β†’
250mg daily on empty stomach
⚑ Take away from iron supplements πŸŒ… Morning empty stomach
?
S. boulardii (Probiotic Yeast)
Shop β†’
250-500mg daily
πŸŒ… With or without food
?
Taurine
Shop β†’
500-2000mg daily with dinner
πŸŒ† Evening with food
?
Grass-Fed Collagen/Gelatin
Collagen β†’Gelatin β†’
1-2 tablespoons daily with meals
β˜€οΈ With meals
?
Zinc (Picolinate/Bisglycinate)
Shop β†’
15-30mg daily with food
⚑ Skip if taking oyster supplement πŸŒ† With dinner
?
NAC (N-Acetyl Cysteine)
Shop β†’
600mg daily on empty stomach
πŸŒ… AM empty stomach
?
Glycine Powder
Shop β†’
3-5g before bed
⚑ Skip if drinking bone broth daily πŸŒ™ Bedtime
?
⏰ Timing
L-Glutamine + Lactoferrin on empty stomach AM. Collagen with meals. Taurine + Zinc with dinner. Glycine before bed.
πŸ”— Gut-Hormone Axis
Your gut metabolizes estrogen (estrobolome), converts T4β†’T3 (20%), and directly impacts cortisol via the vagus nerve. Fix the gut, fix the hormones.
⚠️ Cautions
Die-off reactions: Start low, increase slowly over 2 weeks. Headaches, fatigue, and GI upset can occur initially.
SIBO/IMO: If diagnosed with bacterial overgrowth, some supplements (especially glutamine) may worsen symptoms. Work with a practitioner.
⭐
Foundational Stack
Core Quartet (Only If Diet Gaps Exist)
β–Ό
Magnesium Glycinate
Shop β†’
600-800mg before bed
πŸŒ™ Bedtime
?
Non-Fortified Nutritional Yeast
Shop β†’
1-2 tablespoons daily with meals
πŸŒ… Morning
?
Vitamin C (Camu Camu/Acerola)
Camu Camu β†’Acerola β†’
500-1000mg daily
πŸŒ† Anytime
?
Grass-Fed Collagen/Gelatin
Collagen β†’Gelatin β†’
1-2 tablespoons daily with meals
β˜€οΈ With meals
?
πŸ“‹ Quality Standards
Third-party tested for purity β€’ Minimal or no additives β€’ Non-fortified nutritional yeast β€’ Whole-food vitamin C sources
πŸ”„ Cycling Guidelines
4-8 weeks on, 2-3 weeks food-only break β€’ Re-evaluate needs quarterly based on diet optimization

⚠️ Important Guidelines

Always prioritize food sources before supplements
Cycle supplements (4-8 weeks on, 2-3 weeks off)
NDT requires practitioner supervision
Skip D3 if getting adequate sun exposure
Skip oyster supplement if eating oysters weekly
Skip glycine if consuming bone broth daily
Consult healthcare provider before starting
Stop biotin 3-5 days before lab tests
Separate zinc/copper and calcium/magnesium timing

πŸ”„ Ready to Retest?

After 4-8 weeks of protocol optimization, rescan to track your progress and get updated recommendations based on your body's response.

Get Your Quarterly Rescan β†’

πŸ“… Your Daily Schedule

Β© 2025 Hormora. All rights reserved.

This guide is for educational purposes only. Consult a healthcare provider before making supplementation changes.

⚠️ Disclaimer

This content is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before starting any supplement regimen, especially if you have medical conditions, are pregnant or nursing, or take medications.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

Affiliate Disclosure: This page contains affiliate links. We may earn a commission at no extra cost to you when you purchase through these links.

Β© 2025 Hormora. All rights reserved.